Modern high DPI monitors are fantastic for crisp and detailed visuals, but they can occasionally cause compatibility issues with certain software. For users of SAMSON—the integrative molecular design platform—you might notice that the interface icons appear much smaller than expected on high DPI monitors. This can make navigating the interface cumbersome. Thankfully, there’s an easy fix for this issue, at least on Windows. Let’s walk through the steps to adjust SAMSON’s high DPI scaling behavior to ensure a user-friendly display.
Step-by-Step Guide to Fix Small Icons on Windows
The fix involves tweaking some compatibility settings in Windows. Follow these steps carefully:
- Locate the SAMSON executable: Right-click on the SAMSON program executable and select Properties.
- Access the Compatibility tab: In the Properties window, navigate to the Compatibility tab.

- Adjust the DPI settings: Click on the Change high DPI settings button. In the pop-up window, check the box labeled Override high DPI scaling behavior. Then, set Scaling performed by to System in the dropdown menu.

- Save and restart: Click OK to save the settings and restart SAMSON if it’s already running. When you relaunch, the icons and interface elements should now scale appropriately to your display.
Why Does This Happen?
Many older or specialized software applications may not automatically account for high DPI scaling, especially on development platforms designed to prioritize performance and functionality over aesthetic adjustments. By manually overriding the DPI scaling behavior in Windows, you allow the operating system to ensure that the application looks proportional and readable on your high-resolution monitor.
Final Thoughts
Having trouble seeing small icons can disrupt your workflow and reduce efficiency. By following this guide, users can easily resolve this issue and return to their work in molecular modeling without further visual obstacles. For more troubleshooting tips related to installation, display, or Linux-specific issues, check the full troubleshooting documentation linked below.
To learn more, visit the SAMSON troubleshooting documentation at https://documentation.samson-connect.net/users/latest/troubleshooting/.
SAMSON and all SAMSON Extensions are free for non-commercial use. You can get SAMSON here.
