Long hours in front of glowing molecules can take their toll. If you’re a molecular modeler working late into the night, or simply prefer a more comfortable visual environment, SAMSON’s Dark mode preferences may help reduce eye strain and give…

When preparing molecular animations, every detail can affect clarity and impact. If you’ve ever wanted to make a model gradually appear—rather than just pop into view—the Appear animation in SAMSON can help you do just that. This subtle visual effect…

When working with proteins in PDB format, one of the recurring challenges is understanding how a structure fits into its larger biological context. Many deposition files contain only an asymmetric unit—just a fragment of the full biological assembly. This often…

Understanding molecular motion is crucial in structural biology and molecular design, especially when studying protein-ligand interactions or conformational transitions. But modeling flexible structures like the SARS-CoV-2 spike protein can be technically challenging and time-consuming. Knowing how to simulate such motions…

When preparing molecular presentations or designing animations of molecular mechanisms, one recurring challenge for modelers is tracking how atoms move over time. Whether you’re simulating a docking event, assembling a complex, or simply visualizing structural changes, keeping a clear record…

Computing conformational changes in large macromolecular systems is often time-consuming and computationally intensive. What if you need a representative trajectory between two known structures but can’t afford to run costly molecular dynamics simulations? For molecular modelers looking to visualize and…

When molecular models get large and detailed, navigating and inspecting them in 3D can become visually overwhelming. Cluttered regions, overlapping atoms, or nested structures can make it hard to focus on specific internal areas of interest — especially in dense…

When studying ligand exit pathways, molecular modelers often need a clean export of just the part of the system that matters: the ligand moving along its path. Exporting the full atom trajectories of an entire protein-ligand complex can quickly create…