Are you using a high-resolution monitor and finding that the icons in SAMSON appear unusually small? If so, you’re not alone. This issue can make working on molecular modeling unnecessarily tedious. Thankfully, there’s a straightforward fix for Windows users to ensure your SAMSON experience is both visually comfortable and practical. Let’s walk you through the steps!
Start with the Compatibility Settings
- Locate the SAMSON executable file: Navigate to the folder where SAMSON is installed. The executable file is the program you use to launch SAMSON.
- Open file properties: Right-click on the SAMSON executable and choose Properties from the context menu.
Here’s an example of what the Properties dialog looks like:

Adjust High DPI Settings
- In the properties window, go to the Compatibility tab.
- Click on the Change high DPI settings button.
- In the dialog that appears, check the box labeled Override high DPI scaling behavior.
- For the option Scaling performed by, select System from the dropdown list.
Here’s a snapshot of this step to guide you:

Restart SAMSON
- Once you’ve adjusted the settings, close the properties window to save your changes.
- Restart SAMSON to see the updated icon sizes.
That’s all it takes! With these simple steps, your SAMSON interface should now be optimized for high DPI monitors, making it much easier to enjoy a seamless molecular modeling experience.
If the issue persists or you encounter other challenges, make sure to visit the SAMSON Connect Forum for additional support. You can also explore more troubleshooting tips by checking out the full troubleshooting documentation linked below.
Learn more by visiting SAMSON’s official Troubleshooting page.
Note: SAMSON and all SAMSON Extensions are free for non-commercial use. Get SAMSON today at SAMSON Connect.
