When working on molecular analogs, one of the recurring pain points is figuring out where to introduce chemical modifications. These modifications need to be both chemically justified and relevant for exploring structure-activity relationships. Traditionally, this step requires careful visual inspection…

When visualizing molecular dynamics, it can be frustrating to lose sight of the area you’re most interested in. As the system evolves over time, atoms move, interactions change, and key regions may drift out of view—even if you had carefully…

One common challenge in molecular modeling is presenting how a ligand exits a binding pocket or how molecular components detach over time. Whether for a presentation, a publication, or to explain a concept to collaborators, animating these motions clearly can…

When working on complex molecular systems, even small time savings can improve focus and productivity. If you’re navigating through menus repeatedly in SAMSON, there’s a quicker way to access your assistant: keyboard shortcuts. SAMSON AI, the intelligent assistant powered by…

If you’ve ever worked with large biomolecular systems, you know the frustration of trying to select a specific type of residues, atoms, or structural groups in a sea of data. Manually clicking or scrolling through complex molecular hierarchies isn’t just…

Tracking molecular motion can be essential in areas ranging from free energy calculations to visualizing ligand unbinding. Yet, if you’ve ever tried to get a clean set of coordinates for just a ligand traveling through a protein tunnel, you know…

Navigating a new molecular design platform can be daunting. When you launch SAMSON for the first time, you might be wondering: where do I start? SAMSON’s ability to simulate, visualize, and design molecular systems is broad, but getting past the…

When working with complex molecular systems, full structural minimization can be overkill. Sometimes, modeling efforts focus on just one region of a molecule: the active site, a flexible loop, or a region that just underwent manual editing. In such situations,…

Installing software in a shared or restricted computing environment can be frustrating—especially for molecular modelers working on university or institutional machines where administrative access is often limited. If you’ve ever faced barriers just trying to install tools crucial for your…

If you work in a research lab or academic group, you’ve probably faced the challenge of coordinating and sharing resources with colleagues. Fragmented file sharing, unclear permissions, and never-ending email chains can lead to confusion—and lost time. That’s why more…