Working with molecular design software like SAMSON on a high-resolution monitor can sometimes lead to an unexpected challenge: extra-small icons. High DPI monitors often render software interfaces disproportionately, making icons, buttons, and text hard to see. If you’re a SAMSON user facing this issue on Windows, this guide will help you adjust settings for an optimal experience.
Adjusting SAMSON’s Compatibility Settings
Windows provides a straightforward way to improve the interface scaling of applications like SAMSON on high-resolution displays. Follow the steps below to resolve this issue:
- Locate the SAMSON Executable: Find the SAMSON application executable file on your computer. It’s usually in the SAMSON installation folder.
- Access Properties: Right-click on the SAMSON executable file and select Properties from the context menu.
- Navigate to Compatibility Tab: In the Properties window, switch to the Compatibility tab.
- Adjust High DPI Settings: Under the Compatibility tab, click on the button labeled Change high DPI settings.
- Override DPI Scaling: In the next window, check the box that says Override high DPI scaling behavior. For the dropdown labeled Scaling performed by, select System.
- Apply Changes: Save your changes by clicking OK and close the Properties window.
- Restart SAMSON: If SAMSON was already running, restart the program to apply the updated settings.
These adjusted DPI scaling settings instruct Windows to manage how SAMSON appears on your high-resolution monitor, ensuring icons and text are rendered at a more user-friendly size.
Visual Guide
Need additional clarity? Below are step-by-step visuals to help you through the process:
1. Accessing the Compatibility Tab:

2. Changing High DPI Settings:

Wrap Up
By following these steps, SAMSON’s interface should now display correctly on high DPI monitors, letting you get back to molecular modeling without distractions. For more detailed troubleshooting tips or other potential display-related issues, refer to the original documentation page:
https://documentation.samson-connect.net/users/latest/troubleshooting/
Note: SAMSON and all SAMSON Extensions are free for non-commercial use. Visit SAMSON Connect to get started today!
