When searching for protein conformational transition paths, one of the most common frustrations for molecular modelers is running simulations that are unstable, inaccurate, or—worse—fail to converge entirely. If your ART-RRT runs in SAMSON aren’t giving reliable results, the culprit might…

Molecular modeling often involves learning new software paradigms, interfaces, and numerous tools, which can quickly become overwhelming — especially when you’re in the middle of a research project. If you’ve ever found yourself stuck wondering how to perform a specific…

Creating compelling molecular animations can significantly enhance presentations, teaching, or collaborative discussions. But controlling how the camera moves in 3D space can sometimes feel unintuitive, especially when you want to create subtle perspective shifts without rotating or panning too drastically.…

One often overlooked step in molecular docking workflows — especially when dealing with large compound libraries — is ligand minimization before docking. This step can significantly affect the quality and efficiency of your docking results. In this blog post, we…

For many molecular modelers, the challenge begins once a system has been prepared: where do you find the computational power to run your molecular dynamics simulations? GROMACS is a fast and versatile engine, but preparing your system locally, worrying about…

Creating engaging, informative molecular presentations can be time consuming—especially when you’re trying to smoothly showcase how molecular structures come together. Traditional animations often require manual keyframe positioning or external rendering tools just to achieve a simple assembly effect. That’s where…

Molecular modeling often requires researchers to juggle between different tools—running simulations in one software, visualizing results in another, and scripting custom analyses somewhere else. This not only increases the risk of errors during data transfer, but it also wastes valuable…

Imagine this: you’ve just discovered a useful SAMSON Extension on the SAMSON Connect Marketplace, clicked “Add”, reopened SAMSON with anticipation… but the extension is nowhere to be found. It’s a common pain point for molecular modelers using SAMSON for the…