One of the frequent challenges faced by molecular modelers lies in understanding the stability and dynamics of molecular interactions along a given path. How can we identify stable bonds, fleeting connections, or recurring patterns of interaction between molecular groups? The…

Molecular modelers often struggle with understanding how different parts of a molecular complex interact during dynamic simulations. Are the interactions stable? When do key residues come into contact? How do domain interfaces change over time? These kinds of questions are…

If you’re a molecular modeler looking to stay updated on the latest advancements in your tools, SAMSON’s webinar recordings can be a valuable resource. These webinars delve into the specifics of new features introduced in recent SAMSON releases, helping you…

Molecular modelers working with proteins, RNA, or DNA often face the challenging task of exploring large-scale biomolecular motions, such as opening or closing a binding site. Whether you’re investigating ligand binding or analyzing structural flexibility, understanding these motions can provide…

Molecular modellers frequently struggle with identifying ligand unbinding pathways from protein structures—a critical step in understanding molecular interactions. The SAMSON Ligand Path Finder is specifically designed to address this challenge. If you’ve ever found yourself spending hours manually exploring binding…

When working on molecular modeling, maintaining focus on a specific region of your system during animations can often feel like a complex task. Whether you are exploring molecular trajectories or visualizing specific interactions, losing track of key atoms can disrupt…

For molecular modelers and researchers diving into the world of SAMSON, the installation process might initially seem like a potential hurdle—especially when dealing with systems without admin rights. Thankfully, SAMSON alleviates this concern with its surprisingly straightforward approach to installation.…

Molecular modelers working on protein-ligand complexes often encounter a critical obstacle: parametrizing ligands for molecular dynamics simulations. This step is essential for ensuring accurate simulations but can be daunting, especially when dealing with non-standard or large ligands. In this guide,…